Study to Assess the Safety and Effectiveness of NMRA-335140-501

Running, not enrolling · Phase 3

Conditions studied: Major Depressive Disorder

In brief

This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder (MDD). Participants who completed a parent study investigating the efficacy and safety of NMRA-335140 as a treatment for MDD (ie, NMRA-335140-301, NMRA-335140-302, or NMRA-335140-303), and complete the 6 weeks double-blind treatment, provide informed consent, and meet eligibility criteria, may enter this extension study.

Key facts

Study ID

NCT06029439

Run by

Neumora Therapeutics, Inc.

People needed

1000

Starts

2023-11-10

Expected to finish

2027-06-01

Last updated by the study team

2026-06-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Neumora Investigator Site — Phoenix, Arizona, United States
• Neumora Investigator Site — Bentonville, Arkansas, United States
• Neumora Investigator Site #1 — Little Rock, Arkansas, United States
• Neumora Investigator site — Little Rock, Arkansas, United States
• Neumora Investigator Site — Rogers, Arkansas, United States
• Neumora Investigator site — Bellflower, California, United States
• Neumora Investigator Site — Cerritos, California, United States
• Neumora Investigator Site — Encino, California, United States
• Neumora Investigator Site — Garden Grove, California, United States
• Neumora Investigator Site — Glendale, California, United States
• Neumora Investigator Site — Imperial, California, United States
• Neumora Investigator Site — Irvine, California, United States
• Neumora Investigator Site — Lafayette, California, United States
• Neumora Investigator Site #1 — Long Beach, California, United States
• Neumora Investigator site — Long Beach, California, United States
• Neumora Investigator Site — Los Angeles, California, United States
• Neumora Investigator Site — Newport Beach, California, United States
• Neumora Investigator Site — Oceanside, California, United States
• Neumora Investigator Site #1 — Orange, California, United States
• Neumora Investigator Site — Orange, California, United States
• Neumora Investigator Site — Riverside, California, United States
• Neumora Investigator Site — San Diego, California, United States
• Neumora Investigator Site — San Francisco, California, United States
• Neumora Investigator Site — San Jose, California, United States
• Neumora Investigator site — Huntsville, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.