Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

Completed · Phase 3 · Has a placebo group

Conditions studied: Major Depressive Disorder

In brief

This is a randomized, double blind, placebo controlled, multi-center study to evaluate the effects of NMRA-335140 (formerly BTRX 335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 28 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and meet the eligibility criteria may enter an extension study (NMRA-335140 501).

Key facts

Study ID

NCT06029426

Run by

Neumora Therapeutics, Inc.

People needed

383

Starts

2023-09-20

Expected to finish

2025-01-15

Last updated by the study team

2025-11-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Neumora Investigator Site — Phoenix, Arizona, United States
• Neumora Investigator Site — Bentonville, Arkansas, United States
• Neumora Investigator Site-1 — Little Rock, Arkansas, United States
• Neumora Investigator Site — Little Rock, Arkansas, United States
• Neumora Investigator Site — Rogers, Arkansas, United States
• Neumora Investigator Site — Bellflower, California, United States
• Neumora Investigator Site — Garden Grove, California, United States
• Neumora Investigator Site — Glendale, California, United States
• Neumora Investigator Site — Imperial, California, United States
• Neumora Investigator Site — Lafayette, California, United States
• Neumora Investigator Site — Long Beach, California, United States
• Neumora Investigator Site — Los Angeles, California, United States
• Neumora Investigator Site — Oceanside, California, United States
• Neumora Investigator Site — Orange, California, United States
• Neumora Investigator Site — Riverside, California, United States
• Neumora Investigator Site — San Jose, California, United States
• Neumora Investigator Site #1 — Sherman Oaks, California, United States
• Neumora Investigator Site — Sherman Oaks, California, United States
• Neumora Investigator Site — Temecula, California, United States
• Neumora Investigator Site — Torrance, California, United States
• Neumora Investigator Site — Colorado Springs, Colorado, United States
• Neumora Investigator Site — Gainesville, Florida, United States
• Neumora Investigator Site — Hallandale, Florida, United States
• Neumora Investigator Site — Jacksonville, Florida, United States
• Neumora Investigator Site — Huntsville, Alabama, United States

Full record on ClinicalTrials.gov

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