Dietary Nitrate Functional Gum Effect on Gingivitis and Heart Health

Completed · Not applicable · Has a placebo group

Conditions studied: Gingivitis, Cardiovascular Diseases, Gingival Diseases, Gingival Bleeding, Periodontal Diseases

In brief

The purpose of this research is to determine the effects of a chewing gum containing dietary nitrate to gingival and heart health. Dietary nitrates are commonly found in leafy vegetables and beets. The information learned from the study may help further understand the interconnection of oral health and heart health. The study is looking for individuals who present with mild to moderate gum irritation or bleeding. In the study participants will be randomized into either a group that will use a chewing gum containing dietary nitrate, or use a placebo chewing gum during a three-week period. Participants in the study will have a simple gingival exam, x-rays if needed, and small samples of saliva and blood collected. All participants will also undergo a routine tooth cleaning. Participants will be asked to breathe in a tube to sample the levels of nitric oxide. Finally, participants will have their heart health measured with a device that is like a blood pressure cuff.

Key facts

Study ID

NCT06029283

Run by

University of Maryland, Baltimore

People needed

30

Starts

2024-04-15

Expected to finish

2025-08-01

Last updated by the study team

2025-09-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult subjects with mild to moderate gingivitis, defined with a MGI score of at least 2.0
• Subjects must have a minimum of 20 natural teeth
• Subjects must be able to chew gum

You may not qualify if…

• Significant alveolar bone loss (>3.0 mm CEJ to bone)
• Requirement for antibiotic pre-medication prior to dental procedures
• Systemic antibiotic use in past 14 days to current.
• Use of anti-inflammatory (NSAIDs) or in past 14 days
• Use of anticoagulant therapy or in past 14 days.
• Current smokers
• Pregnancy
• Use of any oral rinses such as, but not limited to chlorhexidine, essential oils, cetylpyridinium chloride during the study.

Where it is running

• University of Maryland School of Dentistry — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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