Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine
Recruiting now · Phase 4
Conditions studied: Anesthesia
In brief
The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine. Specifically, the investigators will be evaluating ease of laryngoscopy, vocal cord view, vocal cord opening, and movement of limbs and coughing during tracheal intubation in order to assess intubation conditions, to compare efficiency and success rate of tracheal intubation between two induction agents and to determine the rate of patient awareness during induction and post-operative recall of paralysis.
Key facts
- Study ID
- NCT06029049
- Run by
- The University of Texas Health Science Center, Houston
- People needed
- 152
- Starts
- 2023-09-13
- Expected to finish
- 2025-07-01
- Last updated by the study team
- 2024-12-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- BMI > 30kg/m2 or Mallampati class III or IV.
- Requiring general anesthesia and endotracheal intubation
You may not qualify if…
- Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease(COPD) and asthma.
- The American Society of Anesthesiologists (ASA) physical status classification > III.
- Patients requiring awake intubation.
- Pregnant women.
- Untreated ischemic heart disease.
- Patients requiring an induction dose of propofol < 1 mg/kg.
- Allergy to propofol, rocuronium, succinylcholine, or sugammadex.
- Patients with renal failure and unknown potassium (K+) level, or patients with K+ level > 5.0
- Personal history of malignant hyperthermia (MH), or family history of MH
- Patients with suspected or diagnosed neuromuscular disease, patients with burn injuries
Where it is running
- The University of Texas Health Science Center at Houston — Houston, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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