Blood Flow Regulation and Neuromuscular Function Post-Stroke
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Stroke
In brief
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.
Key facts
- Study ID
- NCT06027294
- Run by
- Medical College of Wisconsin
- People needed
- 40
- Starts
- 2024-01-11
- Expected to finish
- 2028-06-30
- Last updated by the study team
- 2025-09-25
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Be between 18-85 years of age
- Able to give informed consent
- ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
- English speaking
You may not qualify if…
- History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
- Chronic pain syndrome
- Low back or hip pain that interferes with lower extremity motor testing
- History of head trauma
- Comorbid neurological disorder
- Peripheral vascular disease
- Myocardial infarction in the previous year
- Inability to follow 2 step commands
- Condition where fatiguing contractions or resisted leg contractions are contraindicated
- Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg
- Pregnancy or breastfeeding.
Where it is running
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
- Marquette University — Milwaukee, Wisconsin, United States (enrolling)
Full record on ClinicalTrials.gov
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