Detection of Plasma DNA of Renal Origin in Kidney Transplant Patients
Recruiting now
Conditions studied: Acute Kidney Injury, Renal Transplantation
In brief
Donor-derived cell-free DNA (dd-cfDNA) has been proposed as a potential diagnostic tool to monitor the rejection status of the kidney transplant. It has been suggested that dd-cfDNA is increasing in the blood of kidney transplant patient presenting a graft rejection. In this project, investigators proposed a different approach to predict and characterize kidney transplant rejection/dysfunction based on the quantification of epigenetic signatures present on the donor-cell-free DNA. In 2018, Moss et al. develops a deconvolution model capable of identifying the tissue origin of circulating DNA by taking advantage of its epigenetic properties. The study confirmed that the cell-free DNA circulating in healthy subjects comes mainly from blood cells and endothelial cells, but not from kidney cells. In this study, researchers investigate the evolution of blood renal-specific cell-free DNA amount in patient with chronic kidney disease before and after the transplantation surgery by testing a set of renal-specific epigenetic markers. The purpose of this study is to identify the biological noise of "native kidney" on renal-specific cell-free DNA and to compare it with signal coming from "transplanted kidney".
Key facts
- Study ID
- NCT06026592
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 30
- Starts
- 2024-09-02
- Expected to finish
- 2026-07-09
- Last updated by the study team
- 2025-09-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years old
- With end-stage renal failure
- Summoned for a kidney transplant at Pitié Salpêtrière Hospital
- Having been informed of the study and not objecting to the study having given free and informed written consent for the genetic analysis
- Benefiting from a social security scheme (excluding AME)
You may not qualify if…
- Under legal protective measures (curatorship or guardianship, under judicial safeguard).
Where it is running
- Pitié-Salpétriêre Hospital — Paris, Île-de-France Region, France (enrolling)
Full record on ClinicalTrials.gov
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