2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hypertension

Completed · Not applicable · Has a placebo group

Conditions studied: Menopause, Hypertension

In brief

The objective of this project is to elucidate the effect of L-Citrulline (L-CIT) supplementation on vascular function at rest and during rhythmic handgrip exercise and functional sympatholysis via lower-body negative pressure in postmenopausal women with elevated blood pressure and hypertension.

Key facts

Study ID

NCT06025383

Run by

Texas Tech University

People needed

19

Starts

2023-07-20

Expected to finish

2024-07-01

Last updated by the study team

2025-05-15

Who can join

Age: 50 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Postmenopausal women (defined as the absence of menstruation for at least 1 year).
• Resting systolic blood pressure 120-150 mmHg.
• Between the ages of 50 - 70 years.
• Sedentary (< 120 minutes of exercise/week).
• Body mass index of 25 - 39.9 kg/m2.
• Fasting glucose < 126 mg/dL and HbA1c < 6.5%.

You may not qualify if…

• Body mass index ≥ 40 or < 25 kg/m2.
• Systolic blood pressure > 150 mmHg.
• Taking more than two antihypertensive medications.
• Cardiovascular diseases, type I/II diabetes, musculoskeletal disorders, or cancer.
• Changes in hypertensive medication in the past three months.
• Began or changed hormone replacement therapy in the past 6 months.
• Current smoker.
• Heavy drinking (> 7 alcoholic drinks/week).
• Participants on beta-blockers or other vasodilatory supplements (nitrates).
• Incorporated in a weight loss program and/or aerobic or resistance training program.

Where it is running

• Texas Tech University — Lubbock, Texas, United States

Full record on ClinicalTrials.gov

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