Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
Recruiting now · Not applicable
Conditions studied: Hyperglycaemia (Non Diabetic), Prediabetes
In brief
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.
Key facts
- Study ID
- NCT06025292
- Run by
- University of Arkansas
- People needed
- 20
- Starts
- 2024-09-11
- Expected to finish
- 2027-01-31
- Last updated by the study team
- 2026-06-08
Who can join
Age: 40 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1. Males and females ages 40-65 years.
- 2. BMI 25 to ≤40 kg/m2 (or body fat % ≥25% in males or ≥36% in females)
- 3. Capable of providing informed consent.
- 4. COVID-19 negative and/or asymptomatic.
- 5. Willing to abstain from drinking alcohol or consuming marijuana and CBD products during the 4-day study meal period
- 6. HbA1c: 5.7-6.4% or fasting glucose 100-125 mg/dL
You may not qualify if…
- 1. Participant who does not/will not eat animal protein sources.
- 2. Allergy to wheat, soy, or common ingredients in plant-based protein products.
- 3. Body mass index <25 kg/m2 or >40 kg/m2.
- 4. Hemoglobin <10g/dL at screening.
- 5. Platelets <150,000/uL at screening.
- 6. History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.
- 7. History of gastrointestinal bypass/reduction surgery.
- 8. Pregnant or lactating individuals.
- 9. History of a chronic inflammatory disease (e.g. Lupus, Crohn's disease)
- 10. Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.
- 11. Currently using prescription blood thinning medications.
- 12. Currently using corticosteroid medications (cortisone, hydrocortisone, prednisone, etc.).
- 13. Unable or unwilling to suspend aspirin use for 7 days prior to Visit 3 and Visit 7.
- 14. Unwilling to avoid using protein or amino-acid supplements during participation.
- 15. Unwilling to fast overnight.
- 16. Unwilling to avoid alcohol, marijuana and CBD products for the four study days.
- 17. Participants on glucagon-like-peptide-1 receptor agonist (GLP-1-RA) medications for <1 month or with less than one treatment dose (injection) every two weeks
Where it is running
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States (enrolling)
Full record on ClinicalTrials.gov
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