Obstructive Sleep Apnea as a Risk Factor for Normal Tension Glaucoma and a Crucial Step in Preventing Blindness

Starting soon

Conditions studied: Normal Tension Glaucoma, Obstructive Sleep Apnea

In brief

The purpose of this research study is to learn more about the relationship between Obstructive Sleep Apnea (OSA) and Normal Tension Glaucoma (NTG). OSA is a nighttime disorder of the upper airway that causes an intermittent lack of oxygen while sleeping. NTG is a type of glaucoma that occurs despite the normal intraocular pressure levels, making its detection more difficult. Left untreated, irreversible optic nerve damage and extensive vision loss can result. Previous research has shown some evidence between OSA and the development of NTG. The investigators are researching whether undergoing treatment for OSA would help to improve the vascular health to the retina, and in effect, improve the early signs of visual dysfunction seen with diagnostic testing.

Key facts

Study ID

NCT06023927

Run by

Northwell Health

People needed

100

Starts

2025-09-02

Expected to finish

2028-09-01

Last updated by the study team

2025-06-10

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newly diagnosed subjects with OSA that will undergo CPAP treatment.
• At least 21 years of age
• Best corrected vision of 20/40 or better, spherical Rx < ± 6.0 Diopter, and cylinder <-3.0D
• Ability to follow instructions, and intent to complete all study visits

You may not qualify if…

• High Rx >± 6.0D and cylinder > -3.0D
• Narrow angle glaucoma
• History of any of the following: severe eye trauma, ocular inflammation, previous intraocular surgery except for uncomplicated cataract extraction with posterior chamber intraocular lens implantation.
• Any medical or ocular condition which is not appropriate for participation in the trial (Diabetic retinopathy, and other retinal changes preventing reliable optic disc evaluation) Hypersensitivity to any component of altafluor benox

Where it is running

• Manhattan Eye, Ear, & Throat Hospital — New York, New York, United States
• Manhattan Eye, Ear, & Throat Hospital — New York, New York, United States

Full record on ClinicalTrials.gov

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