Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing

Recruiting now · Not applicable

Conditions studied: Infertility, Genetic Disease, Chromosomal Rearrangement, Aneuploidy

In brief

Infertile women attending for PGT at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF. Subsequently, they will be randomly assigned on the day of oocyte retrieval by a laboratory staff into one of the following two groups in a 1:1 ratio : (1) the microfluidic chip group and (2) the density gradient centrifugation group for sperm preparation and subsequent use in fertilization. Other IVF procedures will be the same as the standard practice of the Centre. Both women and clinicians will be blinded from the group allocation i.e. a double blind study.

Key facts

Study ID

NCT06023472

Run by

Professor Ernest Hung-Yu Ng

People needed

318

Starts

2024-11-01

Expected to finish

2028-11-30

Last updated by the study team

2024-12-06

Who can join

Age: any, up to 43. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Women aged <43 years at the time of ovarian stimulation for IVF
• Women undergoing PGT for monogenic diseases, structural rearrangement of chromosomes or aneuploidy
• Sperm concentration of the raw semen with at least 0.15 million motile sperm per ml or 100 motile sperm per 50 low power field (200x) of observation

You may not qualify if…

• Use of frozen semen for insemination
• Use of donor oocytes and spermatozoa
• Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated;
• Women who had been recruited into this study before and
• Women joining other randomized trials

Where it is running

• Department of Obstetrics and Gynaecology — Hong Kong, Hong Kong, China (enrolling)

Full record on ClinicalTrials.gov

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