Knee Prosthetic Joint Infection Antibiotic Elution

Withdrawn before enrolling

Conditions studied: Prosthetic-joint Infection, Arthroplasty Complications

In brief

Patients presenting with prosthetic joint infections of a total knee replacement who are treated with an antibiotic spacer will be observed prospectively for their response to treatment and antibiotic elution profiles will be measured post-operatively utilizing mass spectrometry from synovial fluid acquired as part of standard of care in the management of prosthetic joint infection. Secondary outcomes including post-operative complications, re-operation rates, and re-admission rates will also be compared.

Key facts

Study ID

NCT06023238

Run by

University of Pittsburgh

People needed

0

Starts

2026-01-05

Expected to finish

2029-12-31

Last updated by the study team

2026-02-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients planned for treatment of a total knee arthroplasty prosthetic joint infection
• Patients greater than 18 years of age
• Patients able to provide informed consent

You may not qualify if…

• Prior history of ipsilateral or contralateral prosthetic joint infection warranting operative management
• Patients less than 18 years of age
• Patients unable to provide informed consent.

Where it is running

• UPMC Shadyside — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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