The MARY-JANE Cannabis and Heart Rhythm Trial
Completed · Not applicable
Conditions studied: Premature Atrial Contractions, Premature Ventricular Contractions
In brief
Despite recreational cannabis now being legal in 23 states, where more than 100 million Americans reside, studies on the actual health effects are limited. This study is a randomized trial, where each participant will be instructed to consume or avoid cannabis on randomly assigned days during a 14-day monitoring period. The goal of this study is to answer the question: "Does cannabis use increase the frequency of 'early' and abnormal heart beats?" During the 14-day period, participants will wear an external heart monitor, a glucose monitor, and a fitness tracker to track heart rhythm, glucose levels, step counts, and sleep health. Participants will use a mobile app or a text messaging service for daily instructions/reminders on cannabis use, and short surveys. The investigators ask that participants smoke or vape cannabis at least once on days they are instructed to consume cannabis. Compelling evidence of heart and other health effects would be important to the clinical care of our patients.
Key facts
- Study ID
- NCT06021613
- Run by
- University of California, San Francisco
- People needed
- 108
- Starts
- 2024-01-18
- Expected to finish
- 2025-05-15
- Last updated by the study team
- 2026-07-22
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Are age 21 or older
- Have a smartphone
- Are able to use the Eureka mobile application and Mosio text messaging software
- Have inhaled cannabis in the past month and on at least four different days in the same week in the past year
- Are willing to consume and abstain from inhaled cannabis for no more than two consecutive days as instructed over the 14-day trial period
- Are able to participate in a location where cannabis use would not break any established laws under any jurisdiction
- Are able to self supply cannabis throughout the study duration
You may not qualify if…
- Currently pregnant or trying to get pregnant
- Have a medical reason to avoid cannabis
- Are unwilling to avoid all forms of cannabis consumption on days instructed to abstain from cannabis
- Are currently taking anti-arrhythmic medications
- Have a history of atrial fibrillation or heart failure
- Have congenital heart disease
- Have an implantable cardioverter-defibrillator or pacemaker
- Have had a previous cardiac ablation procedure
- Are currently taking insulin
- Are unable to read or sign to provide informed consent
Where it is running
- UCSF Medical Center at Parnassus — San Francisco, California, United States
- UCSF Medical Center at Mission Bay — San Francisco, California, United States
Full record on ClinicalTrials.gov
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