Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions
Recruiting now
Conditions studied: Renal Injury, Regional Citrate Anticoagulation, Continuous Renal Replacement Therapy
In brief
It is unclear whether different modes of continuous renal replacement therapy (CRRT) impact post-filter ionized calcium concentrations during regional citrate anticoagulation (RCA) when using calcium-containing replacement fluid. This prospective, single-center, observational cohort study will screen all patients receiving CRRT for eligibility. General clinical information will be collected before commencing CRRT treatment. Patients will be randomly assigned to either the veno-venous hemofiltration (CVVH) or continuous veno-venous hemodialysis (CVVHD) group and switch to the alternative mode in the subsequent treatment session. Pre-filter and post-filter ionized calcium, systemic total and ionized calcium, and effluent total and ionized calcium will be measured 2 hours after the initiation of CRRT. Electrolyte levels, arterial blood gases, hourly citrate dose, and total citrate dose will be recorded every 6 hours until the end of CRRT. The primary outcome is the difference in ionized calcium concentrations at each site over time between the two modes.
Key facts
- Study ID
- NCT06021080
- Run by
- Fujian Provincial Hospital
- People needed
- 30
- Starts
- 2023-10-09
- Expected to finish
- 2026-12-09
- Last updated by the study team
- 2025-08-06
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years old;
- Receiving citrate anticoagulation;
- Obtain Informed consent from patients or next of kin.
You may not qualify if…
- Pregnant or lactating women;
- Allergic to citrate anticoagulants;
- Severe liver dysfunction (total bilirubin levels exceeding two times the normal range);
- Hypoxemia (PaO2 < 60 mmHg);
- Inadequate tissue perfusion (blood pressure < 90/60 mmHg despite high doses of vasoactive agents);
- Hyperlactatemia (lactate> 4 mmol/L);
- Hypernatremia;
- Estimated length of hospital stay < 48h;
- Participated in other studies.
Where it is running
- Fujian Provincial Hospital — Fuzhou, Fujian, China (enrolling)
Full record on ClinicalTrials.gov
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