Molecular Markes of Fibrosis of Endometriosis and Their Use in Predicting Disease Severity

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Conditions studied: Molecular Markers of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity

In brief

The primary aim of the project is to analyse gene expression in individual types of ectopic endometrium (ovarian endometriosis, peritoneal endometriosis, deep infiltrating endometriosis) and compare it with gene expression in eutopic endometrium. The analysis focuses on the identification of genes with significantly increased expression in each type of ectopic endometrium and comparison of their expression with the degree of disease, ovarian reserve and clinical manifestations of the disease (pain, infertility).

Key facts

Study ID

NCT06020482

Run by

General University Hospital, Prague

People needed

120

Starts

2023-04-01

Expected to finish

2026-12-31

Last updated by the study team

2023-08-31

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• women (18-45 years)
• signed informed consent with the study
• absence of hormonal treatment 3 months before the planned procedure
• Inclusion criteria for group A:
• laparoscopically and histologically confirmed endometriosis dg.
• Inclusion criteria for group B:
• patients without endometriosis
• patients who are undergoing an elective laparoscopic or hysteroscopic procedure in our department for another benign indication
• patients with excluded malignant disease

You may not qualify if…

• absence of informed consent
• patients who do not meet the inclusion criteria during surgery
• patient younger than 18 years of age or older than 45 years of age

Where it is running

• General University Hospital in Prague — Prague, Czechia (enrolling)

Full record on ClinicalTrials.gov

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