The Effect of Intermittent Fasting on Brain Health

Completed · Not applicable

Conditions studied: Intermittent Fasting, Aging

In brief

The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.

Key facts

Study ID

NCT06019195

Run by

University of Oklahoma

People needed

32

Starts

2024-05-13

Expected to finish

2026-02-02

Last updated by the study team

2026-02-06

Who can join

Age: 55 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥55 and ≤80 years of age
• Adequate hearing and visual acuity to participate in the examinations
• Ability to read and write in English
• Competence to provide informed consent.
• Mini Montreal Cognitive Assessment ≥12
• Mini Nutritional Assessment ≥12

You may not qualify if…

• Vision or hearing impairment that would impair the ability to complete study assessments
• Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
• Cerebrovascular accident other than TIA within 60 days prior to Visit 0
• Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
• Diabetics prescribed sulfonylureas, meglitinides, and insulin
• Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

Where it is running

• Translational GeroScience Laboratory — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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