A Phase 2a Proof-of-Concept Trial of Bempikibart (ADX-914) for the Treatment of Severe Alopecia Areata (SIGNAL-AA)
Running, not enrolling · Phase 2
Conditions studied: Alopecia Areata
In brief
Part A is a randomized, double-blind, placebo-controlled, multi-center Proof-of-Concept (POC) Trial in subjects with severe Alopecia Areata. All participants in Part A have completed participation. Part B is a multicenter, open-label study to assess the efficacy, safety, and tolerability of bempikibart (ADX-914) in participants with severe Alopecia Areata.
Key facts
- Study ID
- NCT06018428
- Run by
- Q32 Bio Inc.
- People needed
- 75
- Starts
- 2023-09-12
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2026-05-08
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Scottsdale, Arizona — Scottsdale, Arizona, United States
- Fayetteville, Arkansas — Fayetteville, Arkansas, United States
- Hot Springs, Arkansas — Hot Springs, Arkansas, United States
- Encinitas, California — Encinitas, California, United States
- Fountain Valley, California — Fountain Valley, California, United States
- Lomita, California — Lomita, California, United States
- New Haven, Connecticut — New Haven, Connecticut, United States
- Miami, Florida — Miami, Florida, United States
- Tampa, Florida — Tampa, Florida, United States
- Clarksville, Indiana — Clarksville, Indiana, United States
- Bowling Green, Kentucky — Bowling Green, Kentucky, United States
- Burlington, Massachusetts — Burlington, Massachusetts, United States
- Troy, Michigan — Troy, Michigan, United States
- Warren, Michigan — Warren, Michigan, United States
- New York, New York — New York, New York, United States
- New York, New York — New York, New York, United States
- Wilmington, North Carolina — Wilmington, North Carolina, United States
- Bexley, Ohio — Bexley, Ohio, United States
- Clinical Trials — Canton, Ohio, United States
- Mason, Ohio — Mason, Ohio, United States
- Mayfield Heights, Ohio — Mayfield Heights, Ohio, United States
- Portland, Oregon — Portland, Oregon, United States
- Austin, Texas — Austin, Texas, United States
- Frisco, Texas — Frisco, Texas, United States
- Houston, Texas — Houston, Texas, United States
Full record on ClinicalTrials.gov
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