An Imaging Study of Polyvascular Disease

Recruiting now

Conditions studied: Polyvascular Disease

In brief

1. Establish a multimodality imaging database for PVD, improve the one-stop screening process for early PVD based on artificial intelligence, build a full-cycle control information platform, and promote the construction and standardization of a multidisciplinary co-morbidity and co-management diagnosis and treatment model. 2. Based on non-invasive, zero-contrast ocular OCTA combined with one-stop CTA imaging of the heart and brain, construct an integrated "eye-heart-brain" early warning model for PVD, and explore a potential non-invasive and convenient early warning system for PVD. 3. Based on the multi-omics, investigate EVs-mediated intercellular communication network, elucidate the roles and regulatory mechanisms of EVs in the development of PVD, search for potential targets for intervention, and construct an artificial intelligence-based "pan-vascular score" risk assessment system based on the combination of multi-modality imaging and multi-omics biomarkers.

Key facts

Study ID

NCT06016608

Run by

Harbin Medical University

People needed

1100

Starts

2023-10-18

Expected to finish

2025-12-31

Last updated by the study team

2024-12-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Task 1:
• Patients with coronary artery disease (≥50% stenosis in any coronary artery on coronary angiography)
• Age ≥18 years old
• Proposed OCT-IVUS integrated imaging system
• able to provide written informed consent prior to the start of any procedures related to the study.
• Task 2:
• patients with coronary artery disease (coronary angiography reveals ≥50% degree of stenosis in any coronary artery) and patients with stroke or TIA (confirmed by a neurologist)
• Age ≥ 18 years
• able to provide written informed consent prior to the start of any procedures related to the study.

You may not qualify if…

• Task 1:
• severely tortuous/calcified coronary arteries with anticipated difficulty in completing the OCT-IVUS integrated imaging system
• uncontrolled congestive heart failure or acute left heart failure;plan
• claustrophobia;
• left main stem occlusion;
• proposed coronary artery bypass grafting (CABG);
• uncontrolled severe ventricular arrhythmia;
• active bleeding or severe bleeding tendency;
• acute stroke;
• patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ;
• severe renal insufficiency and/or anuria, except in cases where dialysis treatment has been planned;
• contraindications to the application of contrast media;
• patients who are severely uncooperative due to psychiatric or serious systemic illness;
• Patients who, in the opinion of the investigator, are unsuitable for participation in the study.
• Task 2:
• patients who are unable to comply with the follow-up schedule;
• uncontrolled congestive heart failure or acute left heart failure;
• patients with a life expectancy of less than 6 months;
• left main stem occlusion;
• proposed coronary artery bypass grafting (CABG);
• uncontrolled severe ventricular arrhythmia;
• active bleeding or severe bleeding tendency;
• patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ;
• severe renal insufficiency and/or anuria, except in cases where dialysis treatment has been planned;
• contraindications to the application of contrast media;

Where it is running

• The Second Affiliated Hospital of Harbin Medical University — Harbin, Heilongjiang, China (enrolling)

Full record on ClinicalTrials.gov

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