Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients

Recruiting now · Phase 2/Phase 3

Conditions studied: Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

In brief

This clinical trial aims to investigate whether the low treatment intensity (12 mL/kg/hr, low-dose hemodialysis/filtration) or the medium treatment intensity (25 mL/kg/hr, standard-dose hemodialysis/filtration) is more effective and safer for continuous renal replacement therapy in critically ill patients.

Key facts

Study ID

NCT06014801

Run by

Jikei University School of Medicine

People needed

400

Starts

2023-10-30

Expected to finish

2030-06-01

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Sendai Medical Center — Sendai, Miyagi, Japan (enrolling)
• Osaka Medical and Pharmaceutical University Hospital — Takatsuki, Osaka, Japan (enrolling)
• University of Fukui Hospital — Fukui, Japan (enrolling)
• Tsuchiura Kyodo General Hospital — Ibaraki, Japan (enrolling)
• Wakayama Medical University Hospital — Wakayama, Japan (enrolling)
• Jichi Medical University Hospital — Tochigi, Japan (enrolling)
• Jikei University Hospital — Tokyo, Japan (enrolling)
• Keio University Hospital — Tokyo, Japan (enrolling)
• Osaka University Hospital — Osaka, Japan

Full record on ClinicalTrials.gov

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