Personalized Real-Time DBS and PD Mechanisms
Recruiting now · Phase 4
Conditions studied: Parkinson Disease
In brief
A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical neurostimulation, levodopa medication, and computational modeling. The ultimate goal of this study is to inform the development of closed-loop neuromodulation technology that can be programmed and adjusted in real time based on patient-specific neural activity.
Key facts
- Study ID
- NCT06013956
- Run by
- David Escobar
- People needed
- 25
- Starts
- 2023-08-29
- Expected to finish
- 2028-06-30
- Last updated by the study team
- 2026-05-14
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
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