Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome

Recruiting now · Phase 3

Conditions studied: Acute Respiratory Distress Syndrome

In brief

Acute respiratory distress syndrome (ARDS) is a clinical syndrome caused by intrapulmonary and/or extrapulmonary causes, characterized by intractable hypoxemia. Studies have shown that the sympathetic nervous system is over-activated in patients with acute respiratory distress syndrome. A large retrospective study showed a reduction in mortality in ARDS patients treated with oral β1 blockers before admission, and this beneficial effect of β1 blockers applies to ARDS patients with or without cardiac disease. Esmolol is an ultra-short-acting selective β1 receptor blocker. Previous studies have shown that esmolol can improve oxygenation and reduce the levels of inflammatory cytokines and exudate proteins in bronchoalveolar lavage fluid, thereby alleviating pulmonary injury. According to the literature and our previous clinical observations, we made the following hypothesis: When Estolol is applied to various ARDS patients undergoing mechanical ventilation in ICU, it can control the heart rate by inhibiting β-adrenergic receptor, which can ultimately improve the oxygenation index of patients and shorten the mechanical ventilation time. This project intends to include ARDS patients with optimal hemodynamic treatment for 24 hours, whose heart rate is still ≥95 beats/min after conventional treatment, but ≤120 beats/min. They are randomly divided into control group and Esmolol treatment group to study the effects of esmolol on patients' oxygenation index, mechanical ventilation time, hemodynamics, function of various organs and inflammation level. The aim of this study is to optimize the treatment of ARDS patients.

Key facts

Study ID

NCT06013319

Run by

Zhiming Jiang

People needed

178

Starts

2023-02-20

Expected to finish

2026-10-30

Last updated by the study team

2024-03-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meeting the 2012 Berlin diagnostic criteria for acute respiratory distress syndrome;
• Aged between 18-65 years (inclusive);
• 95 times/min ≤ heart rate ≤120 times/min;
• The patient needs to undergo endotracheal intubation mechanical ventilation after condition assessment;
• Obtain the informed consent of the patient or his legal representative.

You may not qualify if…

• Bradycardia and second degree or more atrioventricular block;
• Long-term use of beta-blockers;
• Combined with emphysema, asthma and other β-blocker contraindicated diseases;
• Cardiac insufficiency (NYHA grade Ⅲ or Ⅳ);
• Pregnancy

Where it is running

• Department of Intensive Care Medicine — Jinan, Shandong, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.