Brain Network Dynamics of Depression During Esketamine Treatment

Completed

Conditions studied: Depressive Disorder, Major

In brief

This is a monocentric, observational clinical trial investigating the effect of Esketamine on brain network activity and a belief updating task in people with depression. We investigate the immediate and the long-term effect (approx. 8 weeks) of Esketamine on EEG signals, pupillometry and belief updating and the relation of those effects on depressive symptomatology.

Key facts

Study ID

NCT06012916

Run by

University of North Carolina, Chapel Hill

People needed

8

Starts

2023-07-03

Expected to finish

2024-08-30

Last updated by the study team

2024-09-19

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Major Depressive Disorder
• Receiving Esketamine nasal spray treatment for depression
• Ability to understand study procedures and sign an informed consent.

You may not qualify if…

• None

Where it is running

• Carolina Center for Neurostimulation — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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