Does Mirabegron Increase the Body Heat Generated by the Nervous System

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Thermoregulation

In brief

Acute mirabegron administration has been shown to increase brown fat activity in humans. Long-term mirabegron administration upregulates brown fat, and appears to improve glucose regulation, and change skeletal muscle phenotype.

Key facts

Study ID

NCT06011265

Run by

Christopher Bell

People needed

19

Starts

2023-04-27

Expected to finish

2024-04-30

Last updated by the study team

2024-06-06

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age 18-40 years,
• regular participation in more than 150 minutes of moderate intensity exercise, every week, during the previous two years.

You may not qualify if…

• History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
• contraindication for mirabegron ingestion, such as previously diagnosed liver and/or kidney dysfunction,
• use of medication that may unfavorably interact with mirabegron, including thioridazine (Mellaril™ and Mellaril-S™), flecainide (Tambocor®), propafenone (Rythmol®), digoxin (Lanoxin®) and solifenacin succinate (VESIcare®)
• pregnancy or breast feeding
• habitual use of tobacco/nicotine products (2 or more uses within the previous month)
• any type of bladder dysfunction, taking medication related to bladder issues, or a history of bladder issues.
• Sulfite Allergy '

Where it is running

• Colorado State University — Fort Collins, Colorado, United States

Full record on ClinicalTrials.gov

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