A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS

Running, not enrolling · Phase 2

Conditions studied: Carcinoma, Non-Small-Cell Lung

In brief

The purpose of the study is to assess the efficacy of durvalumab plus tremelimumab in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy in metastatic NSCLC patients with non-squamous histology who have mutations and/or co-mutations in STK11, KEAP1, or KRAS.

Key facts

Study ID: NCT06008093
Run by: AstraZeneca
People needed: 103
Starts: 2024-04-04
Expected to finish: 2028-02-28
Last updated by the study team: 2026-07-02

Who can join

Age: 18 and older, up to 130. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Histologically or cytologically documented Stage IV non-squamous NSCLC not amenable to curative surgery or radiation.
Participants must have tumors with STK11 or KEAP1 or KRAS mutations. Co-mutations are also allowed.
Participants must have tumors that lack activating epidermal growth factor receptor mutations and ALK fusions.
No prior chemotherapy or any other systemic therapy for metastatic NSCLC. Participants who have received prior platinum-containing adjuvant, neoadjuvant, or definitive chemoradiation for advanced disease are eligible, provided that progression has occurred > 6 months from end of last therapy.
No prior exposure to immune-mediated therapy excluding therapeutic anti-cancer vaccines, within 6 months of randomization.
WHO/ECOG performance status of 0 or 1 at enrollment and randomization.
Minimum life expectancy ≥ 12 weeks at randomization.
At least 1 lesion, not previously irradiated, that qualifies as a RECIST 1.1 target lesion at baseline and can be accurately measured at baseline as ≥ 10 mm in the longest diameter with Computed Tomography (CT)/CT- Positron Emission Tomography or Magnetic Resonance Imaging and that is suitable for accurate repeated measurements as per RECIST 1.1 guidelines.
Adequate organ and bone marrow function.
Negative pregnancy test (urine or serum) for women of child-bearing potential
Female participants must be 1 year post-menopausal, surgically sterile, or using one highly effective form of birth control
Male and Female participants and their partners must use an acceptable method of contraception.
Body weight of > 30 kg

You may not qualify if…

Any evidence of acute or uncontrolled diseases or history of allogeneic organ transplant.
Mixed small cell lung cancer and NSCLC histology.
Major surgical procedure within 28 days prior to the first dose of the study intervention or an anticipated need for major surgery during the study.
Active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease [eg, colitis or Crohn's disease], systemic lupus erythematosus, sarcoidosis, granulomatosis with polyangiitis, Graves' disease, rheumatoid arthritis [requiring immunosuppressive systemic therapy, eg, methotrexate, steroids], hypophysitis, uveitis, etc), autoimmune pneumonitis and autoimmune myocarditis. The following are exceptions to this criterion:
Participants with vitiligo or alopecia.
Participants with hypothyroidism (eg, following Hashimoto syndrome) stable on hormone replacement.
Any chronic skin condition that does not require systemic therapy.
Participants without active disease in the last 5 years may be included but only after consultation with the Study Clinical Lead.
Participants with celiac disease controlled by diet alone.
Medical contraindication to platinum-based doublet chemotherapy.
History of another primary malignancy except:
Malignancy treated with curative intent with no known active disease ≥ 2 years before the first dose of study intervention and of low potential risk for recurrence
Adequately resected non-melanoma skin cancer and curatively treated in situ disease.
Persistent toxicities (Common Terminology Criteria for Adverse Events [CTCAE] Grade ≥ 2) caused by previous anti-cancer therapy, alopecia and vitiligo are excluded toxicities.
Participants with Grade ≤ 2 neuropathy can be considered based on Investigator's judgement. Participants with irreversible toxicity that is not reasonably expected to be exacerbated by treatment with study intervention in the opinion of the Investigator may be included (eg, hearing loss).
Spinal cord compression unless asymptomatic and stable.
Participant meets the following:
Symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia (multifocal premature ventricular contractions, bigeminy, trigeminy, ventricular tachycardia), which requires treatment (CTCAE Grade 3), symptomatic or uncontrolled atrial fibrillation despite treatment, or asymptomatic sustained ventricular tachycardia. Participants with atrial fibrillation controlled by medication or arrhythmias controlled by pacemakers may be permitted based on the Investigator judgement with cardiologist consultation recommended.
Any concurrent chemotherapy, investigational product, biologic, or hormonal therapy for cancer treatment. Concurrent use of hormonal therapy for non-cancer-related conditions (eg, hormone replacement therapy) is acceptable.
No radiation therapy is allowed, unless it is 1) definitive radiation that had been administered at least 6 months prior, 2) palliative radiation to brain, with associated criteria for stability or lack of symptoms, or 3) palliative radiation to painful bony lesions (this must comprise less than 30% of the bone marrow)
Patients with suspected brain metastases at screening should have an IV contrast-enhanced MRI (preferred) or IV contrast-enhanced CT/CT-PET of the brain prior to study entry. If brain metastases are detected patients must be treated before randomization. Randomization is only permitted if patients with brain metastases have:
Confirmed stable condition
Returned neurologically to baseline Brain metastases will not be recorded as RECIST target lesions at baseline.
History of leptomeningeal carcinomatosis.
Known to have tested positive for active tuberculosis infection

Where it is running

Research Site — Beverly Hills, California, United States
Research Site — La Jolla, California, United States
Research Site — Los Alamitos, California, United States
Research Site — Los Angeles, California, United States
Research Site — Santa Monica, California, United States
Research Site — Washington D.C., District of Columbia, United States
Research Site — Fort Lauderdale, Florida, United States
Research Site — Jupiter, Florida, United States
Research Site — Ocala, Florida, United States
Research Site — Orlando, Florida, United States
Research Site — St. Petersburg, Florida, United States
Research Site — Atlanta, Georgia, United States
Research Site — Atlanta, Georgia, United States
Research Site — Honolulu, Hawaii, United States
Research Site — Carterville, Illinois, United States
Research Site — Urbana, Illinois, United States
Research Site — Bethesda, Maryland, United States
Research Site — Jamaica Plain, Massachusetts, United States
Research Site — Saint Paul, Minnesota, United States
Research Site — Kansas City, Missouri, United States
Research Site — St Louis, Missouri, United States
Research Site — Billings, Montana, United States
Research Site — Grand Island, Nebraska, United States
Research Site — Lincoln, Nebraska, United States
Research Site — Albany, New York, United States

Full record on ClinicalTrials.gov

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