Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

Recruiting now

Conditions studied: Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease, PreDiabetes

In brief

This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.

Key facts

Study ID

NCT06007404

Run by

University of Michigan

People needed

175

Starts

2023-09-06

Expected to finish

2027-09-01

Last updated by the study team

2026-07-13

Who can join

Age: 14 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between 14 and 18 years of age
• Tanner stage 4 or 5 (mature adult stage of puberty)
• Normal weight (BMI ≥ 5th percentile \& < 85th percentile), overweight (BMI > 86th percentile) \& < 94th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c > 5.7%)
• For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes

You may not qualify if…

• Currently pregnant
• Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management
• Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff
• Allergies or intolerance to milk, soy, or palm oil

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

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