Multiple Ascending-Dose Study of XmAb®27564 in Patients With Psoriasis or Atopic Dermatitis

Stopped early · Phase 1 · Has a placebo group

Conditions studied: Psoriasis, Atopic Dermatitis

In brief

The purpose of this study is to evaluate the safety and tolerability of XmAb27564 following multiple doses among participants with plaque psoriasis and atopic dermatitis.

Key facts

Study ID

NCT06005792

Run by

Xencor, Inc.

People needed

23

Starts

2022-10-10

Expected to finish

2024-11-22

Last updated by the study team

2025-12-02

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The main inclusion and exclusion criteria include, but are not limited to, the following:
• Have active mild-to-severe plaque psoriasis or moderate-to-severe atopic dermatitis according to study-specific criteria
• Weight between 40 to 150 kg, inclusive
• No topical treatments for psoriasis or atopic dermatitis for 2 weeks before randomization
• No phototherapy for psoriasis for 4 weeks before randomization
• Washout of oral treatments for psoriasis or atopic dermatitis for 4 weeks before randomization
• Washout of biologic treatments for psoriasis or atopic dermatitis for 12 weeks before randomization
• Stated willingness to comply with all study procedures (including skin biopsies) and availability for the duration of the study

You may not qualify if…

• Patients with a history of active asthma within 5 years of screening, except those that have well controlled asthma symptoms at screening visit.
• Patients who have had any prior investigational treatment with IL-2 therapies

Where it is running

• Unison Clinical Trials — Sherman Oaks, California, United States
• Clinical Trials Research Institute — Thousand Oaks, California, United States
• Driven Research — Coral Gables, Florida, United States
• San Marcus Research Clinic — Miami Lakes, Florida, United States
• J&S Studies, Inc — College Station, Texas, United States
• Center for Clinical Studies, LTD. LLP — Webster, Texas, United States
• Innovaderm Research Inc. — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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