Oral, Chemosensory and Trigeminal Functions in Allo-HSCT

Recruiting now

Conditions studied: Hematopoietic Stem Cell Transplantation

In brief

The goal of this prospective, cohort study is to learn about smell, taste and trigeminal dysfunction in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The research team hypothesizes that treatment with allo-HSCT will induce: * Distortion of taste and smell and trigeminal functions like cooling, tingling, and burning sensations. * Reduced saliva production leading to oral dryness and dental caries. * Changes in the connectivity of the taste-, smell- and pain-cortical brain regions.

Key facts

Study ID

NCT06003660

Run by

University of Oslo

People needed

70

Starts

2023-08-10

Expected to finish

2028-03-01

Last updated by the study team

2026-05-01

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• patients receiving myeloablative conditioning for a first-time allo-HSCT and diagnosed with either a leukemia or a myelodysplastic syndrome

You may not qualify if…

• disorders affecting the oral cavity including poor tooth-status
• those using drugs affecting the gustatory/olfactory functions
• those with brain disorders
• those who have a chronic disorder affecting the immune system, have cancer or who are pregnant.

Where it is running

• University of Oslo — Oslo, Oslo, Norway (enrolling)

Full record on ClinicalTrials.gov

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