Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements
Enrolling by invitation
Conditions studied: Depression, Major Depressive Disorder
In brief
The purpose of the current study is to perform a unified, homogeneous data collection protocol that includes a large cohort of patients undergoing different treatment options for Major Depressive Disorder (MDD) as an avenue for investigating optimal biomarkers for depression treatments on an individual patient level.
Key facts
- Study ID
- NCT06002100
- Run by
- Kernel
- People needed
- 540
- Starts
- 2023-08-14
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2025-12-12
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ketamine cohort
- Adult between the ages of 18 - 65, inclusive at time of enrollment
- Primary diagnosis of MDD as defined by DSM-5
- Determined by clinic to be eligible for ketamine treatment and agrees to receive ketamine treatment
- Agrees to start ketamine treatment in conjunction with study participation to capture pre-treatment measurements accurately
- Has not received a ketamine treatment course in the past 12 months
- Has not received a TMS treatment course in the past 3 months
- Ability to consent for themselves
- Fluency in English (speaking and reading)
- SPRAVATO cohort
- Adult between the ages of 18 - 75, inclusive at time of enrollment
- Primary diagnosis of MDD as defined by DSM-5
- Determined by clinic to be eligible for SPRAVATO treatment and agrees to receive SPRAVATO treatment
- Agrees to start SPRAVATO treatment in conjunction with study participation to capture pre-treatment measurements accurately
- Has not received a ketamine or SPRAVATO treatment course in the past 12 months
- Has not received a TMS treatment course in the past 3 months
- Ability to consent for themselves
- Fluency in English (speaking and reading)
- TMS cohort
- Adult between the ages of 18 - 65, inclusive at time of enrollment
- Primary diagnosis of MDD as defined by DSM-5
- Determined by clinic to be eligible for TMS treatment and agrees to receive TMS treatment
- Agrees to start TMS treatment in conjunction with study participation to capture pre-treatment measurements accurately
- Has not received a TMS treatment course in the past 12 months
- Has not received a ketamine or SPRAVATO treatment course within the last 3 months
You may not qualify if…
- Is or may be pregnant (for participant of childbearing potential [POCBP]), even if they have been cleared to receive the depression treatment
- Unable or unwilling to wear the TD-fNIRS headset
- Has had ECT in the past 3 months
- Major visual or auditory deficits that would prevent study task completion
- Hospitalizations and/or unstable health/medical condition/treatment in the last 30 days
- Major medical illnesses and psychiatric conditions including:
- Alzheimer's/Mild Cognitive Impairment
- Parkinson's disease
- Motor neuron diseases
- Multiple Sclerosis
- Brain Tumor
- Stroke
- Encephalitis
- Meningitis
- Epilepsy
- TBI with serious results (coma, unconscious for >2 hrs, or skull fracture)
- Current serious psychiatric conditions (bipolar disorder, schizophrenia, or psychosis)
- Any other clinically significant medical condition or circumstance that, in the opinion of the Investigator, could affect patient safety, preclude evaluation of response, interfere with the ability to comply with study procedures, or prohibit completion of the study
- Not an appropriate candidate for the study in the judgment of the investigator(s)
Where it is running
- BrainHealth Solutions — Costa Mesa, California, United States
- Kadima Neuropsychiatry Institute — La Jolla, California, United States
- Kaizen Brain Center, LLC — La Jolla, California, United States
- Bespoke Treatment — Los Angeles, California, United States
- UCLA TMS — Los Angeles, California, United States
- Bespoke Treatment — Los Angeles, California, United States
- Acacia Clinics — Sunnyvale, California, United States
- Metro Psychiatry Inc. — Columbus, Ohio, United States
- Seattle Neuropsychiatric Treatment Center — Bellevue, Washington, United States
- Seattle Neuropsychiatric Treatment Center — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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