HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis
Running, not enrolling · Phase 2
Conditions studied: Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Chronic Myeloid Leukemia, Chronic Lymphocytic Leukemia, Myeloproliferative Neoplasm, Lymphoma, Chronic Myelomonocytic Leukemia, Pro-Lymphocytic Leukemia, Myelofibrosis
In brief
The goal of this clinical trial is to determine the effectiveness of Reduced Dose Post-Transplant Cyclophosphamide (PTCy) in patients with hematologic malignancies after receiving an HLA-Mismatched Unrelated Donor (MMUD) . The main question\[s\] it aims to answer are: * Does a reduced dose of PTCy reduce the occurrence of infections in the first 100 days after transplant? * Does a reduced dose of PTCy maintain the same level of protection against Graft Versus Host Disease (GvHD) as the standard dose of PTCy?
Key facts
- Study ID
- NCT06001385
- Run by
- Center for International Blood and Marrow Transplant Research
- People needed
- 313
- Starts
- 2023-12-08
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2026-02-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic Arizona — Phoenix, Arizona, United States
- Honor Health — Scottsdale, Arizona, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- City of Hope — Duarte, California, United States
- University of California San Francisco — San Francisco, California, United States
- Stanford University — Stanford, California, United States
- Colorado Blood Cancer Institute at Presbyterian St. Luke's — Denver, Colorado, United States
- Mayo Clinic Jacksonville — Jacksonville, Florida, United States
- University of Miami Sylvester Cancer Center — Miami, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Emory University — Atlanta, Georgia, United States
- Greenbaum Cancer Center University of Maryland — Baltimore, Maryland, United States
- Tufts University — Boston, Massachusetts, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Barnes Jewish Hospital / Washington University — St Louis, Missouri, United States
- Memorial Sloan Kettering Cancer Center - Adults — New York, New York, United States
- University of North Carolina — Chapel Hill, North Carolina, United States
- Ohio State Medical Center — Columbus, Ohio, United States
- Oregon Health & Science University — Portland, Oregon, United States
- The Center for Bone Marrow Transplantation at Geisinger — Danville, Pennsylvania, United States
- Abramson Cancer Center — Philadelphia, Pennsylvania, United States
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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