Alcohol and Cannabis Concentrates Co-Administration

Completed · Not applicable

Conditions studied: Alcohol Use Disorder, Cannabis Use

In brief

The goal of this study is to learn about the effects of combining alcohol with cannabis concentrate products which contain high levels of THC. The main question\[s\] it aims to answer are, 1) How does the order in which someone consumes THC and alcohol in a given co-use session impact outcomes such as blood alcohol level, heart rate or subjective drug effects, and 2) how does THC percentage in cannabis influence outcomes following alcohol and cannabis co-administration. Participants will be scheduled for our mobile lab to come to their residence. During the session, they will: * consume a standardized dose of alcohol as well as use their own preferred cannabis concentrate product. * they will then remain in our mobile lab for about 4 hours and complete some surveys as well as do some cognitive tasks on an iPad every 30 minutes. * They will also have their blood drawn three times throughout the session, and will periodically be asked to blood into a breathalyzer to measure blood alcohol level. Researchers will compare people who use alcohol prior to cannabis to those who use cannabis prior to alcohol to determine whether order of use impacts outcomes.

Key facts

Study ID

NCT05999344

Run by

University of Colorado, Denver

People needed

146

Starts

2021-12-16

Expected to finish

2024-08-01

Last updated by the study team

2025-11-18

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 21-65 years old,
• Heavy drinkers (for men, >4 drinks in one occasion, or >14 drinks per week; for women, >3 drinks in one occasion, or >7 drinks per week)
• Regular users of legal-market cannabis (at least 3x/week in past 3 months)
• Have experience using cannabis concentrates within the last year
• Willing to obtain a concentrate product of their choice for use in the study.

You may not qualify if…

• Diagnosed with or seeking treatment for alcohol use disorder (AUD) or other substance use disorder (SUD)
• Pregnant, breastfeeding or trying to become pregnant
• Meet criteria for psychotic, bipolar or major depressive disorder with suicidal ideation, or history of these disorders
• Current use of psychotropic (except anti-depressants) or steroid medications
• Report illicit drug use in past 60-days or fail drug screen (drug screen tests for the presence of amphetamines, benzodiazepines, cocaine, THC, methamphetamine and opioids; only THC is allowed to be present in urine in order to be eligible to participate in the study
• Major medical condition contraindicating alcohol and/or cannabis consumption (e.g., liver disease, heart disease, or being told by a doctor that it is unsafe to consume alcohol or cannabis due to a medical condition)
• Have participated in another research study in the past 8 weeks.

Where it is running

• Colorado State University — Fort Collins, Colorado, United States

Full record on ClinicalTrials.gov

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