Effect of Repetitive TMS on Executive Function in Alcohol Use Disorder

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Alcohol Use Disorder

In brief

Alcohol Use Disorder (AUD) is a major public health problem that affects the physical, social, family, and mental integrity of the sufferer. Behavioral self-regulation is compromised in AUD, and a benefit has been reported with the application of repetitive transcranial magnetic stimulation and emotional self-regulation. The aim of this study is to investigate the efficacy of high-frequency rTMS to improve executive functions in patients in abstinence from AUD.

Key facts

Study ID

NCT05997212

Run by

Universidad Nacional Autonoma de Mexico

People needed

44

Starts

2024-03-16

Expected to finish

2026-11-01

Last updated by the study team

2025-02-10

Who can join

Age: 25 and older, up to 59. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women of 25 to 59 years old
• The reading level of at least 6th grade of primary (equivalent to fifth grade of elementary school).
• Alcohol users with and AUDIT ≥ 20 puntos
• Abstinence from alcohol consumption from 8 weeks to 5 years, with CIWA-Ar scale scores ≤ 9 points.
• No disabling neuropsychiatric conditions (i.e. Schizophrenia)
• No substance use disorders except alcohol and nicotine.
• BrAC (Breath Alcohol) = 0.00 mg/dl in each of the assessments.
• No traces of alcohol consumption using urine test strips.
• No contraindications for TMS therapy.

You may not qualify if…

• Individuals with symptoms of severe agitation or who are unable to cooperate in the study
• History of epilepsy
• Sudden onset of stroke, focal neurological findings such as hemiparesis, sensory loss, visual field deficits and lack of coordination.
• Seizures or gait disturbances
• History of severe psychiatric disorders.
• Alterations in a conventional electroencephalogram.
• Pacemakers or intracranial metallic objects.
• Elimination criteria
• At the subject's request
• The presence of adverse incidents that deteriorate the subject's health and would limit continuation of rTMS treatment.
• Exacerbation of cognitive or behavioral symptoms during treatment.

Where it is running

• Unidad de Resonancia Magnética — Querétaro City, Querétaro, Mexico (enrolling)

Full record on ClinicalTrials.gov

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