Objective Concussion Assessment Using MRI and Metabolomics

Recruiting now

Conditions studied: Concussion, Brain

In brief

Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects. Unfortunately, concussions can be hard to diagnose and many people have lasting post-concussion symptoms such as headaches, difficulty concentrating, and light sensitivity. Recent studies have shown that advanced magnetic resonance imaging (MRI) techniques can identify subtle brain changes caused by a concussion. This study aims to track concussions over time measuring MRI brain scans and post-concussion symptoms to gain a better understand how the brain is affected in comparison to symptoms.

Key facts

Study ID

NCT05993351

Run by

St. Joseph's Healthcare Hamilton

People needed

100

Starts

2023-08-11

Expected to finish

2026-12-15

Last updated by the study team

2025-05-15

Who can join

Age: 9 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged between 9-50
• Recently sustained a concussion (within the last 2 weeks)

You may not qualify if…

• Aged 8 and younger or 51 and older
• Unable to provide consent (e.g., poor English language skills, etc.)
• History of liver or kidney disease
• MRI contraindications:
• Pacemaker
• Stent
• Joint prothesis
• Implanted devices
• Claustrophobia
• Pregnant
• Permanent piercings
• Chronic/abusive use of alcohol and/or illicit drugs
• Previous stroke or moderate/severe traumatic brain injury, subarachnoid hemorrhage, or intracranial hemorrhage
• Healthy control participants must not have a concussion history or recently sustained a concussion

Where it is running

• Imaging Research Center at St. Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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