Neoadjuvant Radiotherapy and Immediate Implant-Based Breast Reconstruction

Recruiting now · Not applicable

Conditions studied: Breast Cancer, Implant Breast Reconstruction, Neoadjuvant Radiotherapy

In brief

Neoadjuvant radiotherapy(NART) followed by mastectomy and immediate DIEP flap reconstruction is feasible and technically safe. However, reports of NACT followed immediate implant-based breast reconstruction are rare. Some studies have shown that NART followed immediate implant-based breast reconstruction seems feasible and can be safely attempted. It's well known that radiotherapy after implant-based breast reconstruction have negative effects on implant and cosmetic results. So, investigators conducted a polit study to learn about acute post-surgical complications following skin-sparing mastectomy and immediate implant-based breast reconstruction after NART.

Key facts

Study ID

NCT05992870

Run by

Hubei Cancer Hospital

People needed

40

Starts

2023-07-08

Expected to finish

2025-10-31

Last updated by the study team

2025-03-17

Who can join

Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women >18 years with histopathologically-confirmed breast cancer, who:
• require mastectomy for any reason
• a known indication for (adjuvant) radiotherapy
• require implant-based breast reconstruction

You may not qualify if…

• Inability to give informed consent
• MDT unable to make recommendation for radiotherapy based on pre-operative histopathological and imaging findings
• Previous history of breast cancer or another malignancy for which radiotherapy of the breast or axilla
• Pregnant or lactating
• inflammatory breast cancer

Where it is running

• Xinhong Wu — Wuhan, Hubei, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.