A Study of TAK-279 in Adults With or Without Kidney Problems

Completed · Phase 1

Conditions studied: Renal Impairment, Healthy Volunteers

In brief

The main aim of this study is to find out how the body processes 1 dose of TAK-279 (pharmacokinetics) in participants with kidney problems compared to participants without kidney problems. Other aims are to check for side effects from TAK-279 and to learn how well participants tolerate 1 dose of TAK-279. The participants will need to stay at the clinic for 11 days.

Key facts

Study ID: NCT05992155
Run by: Takeda
People needed: 24
Starts: 2023-09-27
Expected to finish: 2024-05-28
Last updated by the study team: 2024-06-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

A. Participants with RI:
The participants must fulfill the following inclusion criteria to be eligible for participation in the study (participants who do not qualify based on a reversible condition or mild intercurrent illness may be re-screened after the condition is resolved. Screening tests may be repeated if in the Investigator's opinion the test needs to be repeated):
Understands the study procedures in the informed consent form (ICF) and be willing and able to comply with the protocol.
Adult male or female participant aged ≥18 years, at screening.
Has a body weight greater than 50 kg and has a body mass index (BMI) ≥18.0 and ≤39.0 kilograms per meters squared (kg/m\^2), at screening.
Continuous non-smoker or moderate smoker (≤10 cigarettes/day or the equivalent [including electronic cigarettes]) before screening. Participant must agree to smoke no more than 5 cigarettes or equivalent/day (including electronic cigarettes) from the 7 days prior to TAK-279 dosing.
Aside from RI, be sufficiently healthy for study participation based upon medical history, physical examination, vital signs, electrocardiograms (ECGs), and screening clinical laboratory profiles, as deemed by the Investigator or designee, including:
Supine blood pressure (BP) is ≥90/40 mmHg (asymptomatic) and ≤180/100 mmHg, at screening;
Supine pulse rate (PR) is ≥40 beats per minute (bpm) and ≤99 bpm, at screening;
Liver function tests including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin within the upper limit of normal (ULN) at screening and at check-in.
Creatine phosphokinase (CPK) ≤ ULN at the screening visit and at check-in.
Amylase and lipase ≤ ULN at the screening visit and at check-in.
Estimated glomerular filtration rate (eGFR) based on the Modification of Diet in Renal Disease (MDRD) equation at screening as follows,
Severe RI: <30 milliliters per minute (mL/min), not on dialysis;
Moderate RI: 30-59 mL/min.
Has chronic RI for at least 3 months before screening, and the RI must be stable, i.e., no significant changes (i.e., ≥30%) in renal function in the 30 days preceding screening (or since the last visit if within 6 months before screening) and treatment with stable doses of medication.
Female participants of childbearing potential agree to comply with highly effective contraceptive requirements of the protocol.
Male participants must agree to comply with effective contraceptive requirements of the protocol.
B. Healthy Participants:
Understands the study procedures in the ICF, and be willing and able to comply with the protocol.
Adult male or female participants aged ≥18 years, at screening. Participant will be matched by age (±10 years) and sex to a participant with severe RI (Part A) and/or a participant with moderate RI (Part B).
Has a body weight greater than 50 kg and has a BMI ≥18.0 and ≤39.0 kg/m2, at screening. Participant will be matched by body weight (±15 kg) to a participant with severe RI (Part A) and/or a participant with moderate RI (Part B).
Continuous non-smoker or moderate smoker (≤10 cigarettes/day or the equivalent [including electronic cigarettes]) before screening. Participant must agree to smoke no more than 5 cigarettes or equivalent/day (including electronic cigarettes) from the 7 days prior to TAK-279 dosing.
Medically healthy with no clinically significant medical history, physical examination, vital signs, ECGs, and screening clinical laboratory profiles, as deemed by the Investigator or designee, including:
Supine BP is ≥90/40 mmHg and ≤150/95 mmHg, at screening;

You may not qualify if…

A. Participants with RI:
The participant must be excluded from participating in the study if the participant:
Is mentally or legally incapacitated or has significant emotional problems at the time of screening or expected during the conduct of the study.
Has history or presence of clinically significant medical or psychiatric condition or disease (aside from RI) in the opinion of the Investigator or designee.
Has history of any illness that, in the opinion of the Investigator or designee, might confound the results of the study or poses an additional risk to the participant by their participation in the study.
Has a history of any of the following:
Active infection or febrile illness within 7 days prior to dosing, as assessed by the Investigator or designee;
Symptoms suggestive of systemic or invasive infection requiring hospitalization or treatment within 8 weeks prior to dosing;
Chronic or recurrent bacterial disease, including but not limited to chronic pyelonephritis or cystitis, chronic bronchitis/pneumonitis, osteomyelitis, or chronic skin ulcerations/infections or fungal infections (except superficial nailbed mycosis);
An infected joint prosthesis unless that prosthesis has been removed or replaced within 60 days prior to dosing;
Opportunistic infections (eg, Pneumocystis jirovecii pneumonia, histoplasmosis, coccidiomycosis);
Cancer or lymphoproliferative disease with the exception of successfully treated nonmelanoma skin cancer (NMSC) or basal cell carcinoma and/or localized carcinoma in situ of the cervix;
Known or suspected condition/illness that is consistent with compromised immunity, including but not limited to any identified congenital or acquired immunodeficiency; splenectomy;
Has had a failed renal transplant or a nephrectomy.
Has history or presence of alcoholism and/or drug abuse within the past 6 months prior to dosing, as determined by the Investigator or designee.
Has history or presence of clinically significant hypersensitivity or idiosyncratic reaction to the study drug or related compounds.
Female with a positive pregnancy test at screening or check-in or who is lactating.
Has ECG abnormalities that are considered clinically significant and would pose an unacceptable risk to the participant if he or she participated in the study, in the opinion of the Investigator or designee.
Has positive results for the urine or saliva drug screen at screening or check-in, unless the positive drug screen is due to prescription drug use that is approved by the Investigator or designee and Sponsor.
Has positive results for urine or breath alcohol screen at screening or check-in.
Unable to refrain from or anticipates the use of any medication or substance (including prescription or over-the-counter, vitamin supplements, natural or herbal supplements) for the prohibited time period.
Has been on a diet incompatible with the on-study diet, in the opinion of the Investigator or designee, within the 30 days prior to dosing and throughout the study.
Has made a donation of blood or had significant blood loss within 56 days prior to dosing.
Has made a plasma donation within 7 days prior to dosing.
Participated in another clinical study within 30 days prior to dosing. The 30-day window will be derived from the date of the last dosing in the previous study to Day 1 of the current study.

Where it is running

Clinical Pharmacology of Miami — Miami, Florida, United States
Orlando Clinical Research Center — Orlando, Florida, United States
Research by Design — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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