Sevoflurane General Anesthetic and Spatial Memory in Humans

Recruiting now

Conditions studied: Spatial Memory Disorder

In brief

The goal of this observational study is to learn about the effect of general anesthetic on spatial memory in adults who will undergo to an elective surgery. The main question it aims to answer is: • A surgical event under general anesthesia with sevoflurane transiently impairs spatial memory in humans and induces an increase in inflammatory cytokines. Participants will perform a virtual maze test and plasma samples will be taken before and after surgery.

Key facts

Study ID

NCT05991817

Run by

University of Chile

People needed

22

Starts

2023-08-14

Expected to finish

2025-12-30

Last updated by the study team

2025-11-20

Who can join

Age: 30 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Candidate for elective laparoscopic surgery of cholecystectomy.
• Age 30 to 50 years.

You may not qualify if…

• Visual or hearing difficulties.
• Malignant hyperthermia.
• Being treated with centrally acting drugs, such as anxiolytics, antidepressants, antipsychotics, anticonvulsants, anticholinergics, and first-generation antihistamines.
• Present a disorder of the sphere of neuropsychiatry
• Substance abuse disorder.

Where it is running

• Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chile — Santiago, RM, Chile (enrolling)
• Hospital Clinico de la Universidad de Chile — Santiago, RM, Chile (enrolling)

Full record on ClinicalTrials.gov

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