The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
Recruiting now · Phase 4
Conditions studied: Postoperative Delirium, Major Noncardiac Surgery, Postoperative Cognitive Dysfunction
In brief
Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality. The prevention of postoperative delirium has been classified as a public health priority. However, so far data regarding possible intraoperative interventions to reduce the incidence of postoperative delirium is very scarce. Due to the more rapid wash-in and wash-out times of desflurane as compared to sevoflurane or propofol it seems reasonable that desflurane might be beneficial for the prevention of postoperative delirium. Therefore, we evaluate the effect of maintenance of anesthesia using desflurane, sevoflurane or propofol on postoperative delirium in elderly patients undergoing moderate- to high-risk major noncardiac surgery.
Key facts
- Study ID
- NCT05990790
- Run by
- Medical University of Vienna
- People needed
- 1332
- Starts
- 2023-09-03
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2025-04-30
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Provide written informed consent
- ≥65 years of age
- Scheduled for elective major noncardiac surgery with estimated time of surgery ≥ 2 hours
You may not qualify if…
- Patients undergoing emergency surgery
- BMI > 45 kg/m\^2
- History of diagnosed dementia
- Language, vision, or hearing impairments that may compromise cognitive assessments
- History of malignant hyperthermia
- History of structural muscle disease
- History of organ transplantation (kidney, liver, lung, heart)
- Patients undergoing hyperthermic intraperitoneal chemotherapy
- ICU patients undergoing surgery
Where it is running
- Medical University of Innsbruck — Innsbruck, Austria (enrolling)
- Medical University of Vienna — Vienna, Austria (enrolling)
Full record on ClinicalTrials.gov
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