Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA
Recruiting now
Conditions studied: Respiratory Failure, Weaning Failure
In brief
the introduction of new MV modalities has shown promising results in reducing the incidence of weaning failure, mainly due to a more physiologic approach which allows respiratory muscle preservation. Among them, the Neurally Adjust Ventilatory Assist (NAVA) seemed to be associated with lower incidence of weaning failure and subsequent duration of mechanical ventilation, compared to standard modalities like the Pressure Support Ventilation (PSV) . Moreover, NAVA allows the evaluation of the diaphragm electrical activity (EAdi), an index of diaphragmatic neural respiratory drive. However, no study has compared TFic values during PSV and NAVA modalities in patients with difficult weaning from MV admitted in ICU.
Key facts
- Study ID
- NCT05990348
- Run by
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- People needed
- 20
- Starts
- 2022-07-01
- Expected to finish
- 2025-09-30
- Last updated by the study team
- 2024-10-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- patients who have failed at least one weaning attempt
- mechanical ventilation for at least 24 hours
You may not qualify if…
- Pregnancy
- Obesity (Body Mass Index > 35 kg/m2)
- Contraindication to the insert of a nasogastric tube
- Neuromuscular diseases
Where it is running
- Giorgia Spinazzola — Rome, Italy (enrolling)
Full record on ClinicalTrials.gov
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