Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Completed · Not applicable
Conditions studied: Heart Failure, Heart Failure With Reduced Ejection Fraction
In brief
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality and adverse events (hospitalization or urgent outpatient visits for HF), along with diminished quality of life. Despite convincing data that evidenced-based, guideline-directed medical therapies (GDMT) improve mortality and heart failure-related events, there remains insufficient utilization of these life-saving drugs (evidence-based beta-blockers (EBBB), angiotensin-neprilysin inhibitors (ARNI)/ angiotensin converting enzyme inhibitors (ACEi)/ angiotensin receptor blockers (ARB), mineralocorticoid receptor antagonists (MRA) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with HFrEF. The primary objective of this study is to implement and evaluate a multifaceted, interdisciplinary intervention to improve GDMT use, reduce mortality, and reduce future heart failure events in patients with HFrEF.
Key facts
- Study ID
- NCT05990296
- Run by
- Geisinger Clinic
- People needed
- 4306
- Starts
- 2023-08-01
- Expected to finish
- 2025-05-17
- Last updated by the study team
- 2025-09-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged 18 years or older AND
- Completed visit at included Geisinger cardiology outpatient clinics (office visit or telemedicine) AND
- Clinicians are on a list of currently active Geisinger clinicians in outpatient cardiology clinics who can prescribe heart failure medications AND
- Active problem list diagnosis of HFrEF at time of Cardiology clinic encounter OR Left Ventricular Ejection Fraction (LVEF) < 40: most recent to the cardiology clinic encounter within 2 years of the visit.
You may not qualify if…
- Currently in hospice or palliative care (ICD 10 code: Z51.5)
- Patient is allergic to each category of GDMT
- Patient is prescribed medications from all four categories of GDMT, including ARNI specifically
Where it is running
- Geisinger Cardiology Clinics — Danville, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.