Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
Recruiting now · Phase 1
Conditions studied: Hypertension in Pregnancy
In brief
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes. The primary objective of this pilot study is to determine if anti-HTN treatment to BP\<130/80mmHg in pregnant patients with stage 1 HTN is associated with a difference in birthweight percentile at delivery. Patients with stage 1 hypertension in pregnancy will be randomized to BP goals of \<130/80mmHg or usual care to treatment only if BPs ≥140/90mmHg. For this pilot, the investigator will randomize a total of 74 eligible participants, 37 to active treatment to BP\<130/80mmHg and 37 to usual care.
Key facts
- Study ID
- NCT05989581
- Run by
- University of Alabama at Birmingham
- People needed
- 74
- Starts
- 2024-04-24
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-04-09
Who can join
Age: 14 and older, up to 89. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Viable singleton gestation
- No fetal anomalies
- Blood pressures 130-139/80-89mmHg on two occasions at least 4 hours apart prior to 20 weeks gestation
- Planning to deliver at UAB Hospital
- No indication for pregnancy termination
- Receiving care at the UAB prenatal clinics
You may not qualify if…
- Declines Randomization
- Known diagnosis of chronic hypertension ( BP ≥ 140/90mmHg) or current antihypertensive medication use
- Fetal demise diagnosed prior to enrollment
- Known major structural of chromosomal abnormalities prior to enrollment
- Contraindication to first line antihypertensive (Nifedipine/ Labetalol)
- Comorbidities requiring BP goals < 130/80mmHg
Where it is running
- UAB — Birmingham, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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