Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies

Recruiting now · Phase 2/Phase 3

Conditions studied: Surgical Site Infection, Surgical Wound, Surgical Incision, Emergency Laparotomies, Laparotomies, Post Operative Wound Infection, Wound Infection, Seroma

In brief

The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients undergoing emergency laparotomies. The main question it aims to answer are: * Incidence of SSI after intervention * Length of hospital stay Participants will be randomly assigned to two groups receiving either of the two groups: Group A: 1000ml of IOWI with saline solution prior to incision closure Group B: The incisional wound will be closed conventionally without irrigation. Researchers will compare groups A( experimental group) and B (control group) to compare the incidence of superficial surgical site infections after intervention.

Key facts

Study ID

NCT05989386

Run by

Dow University of Health Sciences

People needed

200

Starts

2023-04-29

Expected to finish

2025-12-29

Last updated by the study team

2025-06-18

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Patients undergoing emergency laparotomy under the care of surgical-6 unit of Dr. Ruth K. M. Pfau Civil Hospital Karachi
• The age of patients should be between 18-60 years old.

You may not qualify if…

• Diabetic patients
• Immune-suppressed patients
• Patients taking steroids
• Patients undergoing chemo-radiotherapy.
• Pregnant females
• Previous abdominal surgery within the last 30 days.
• Presence of concurrent abdominal wall infections.
• Trauma Laparotomies
• Large Bowel perforations

Where it is running

• Dr. Ruth K. M. Pfau Civil Hospital Karachi — Karachi, Sindh, Pakistan (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.