Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity

Recruiting now

Conditions studied: Arteriosclerosis, Acute Myocardial Infarction, Cardiovascular Events, Menopause

In brief

Women and men show marked differences in cardiovascular risk profile and outcome. Women experience fewer cardiovascular events than men before menopause, but this relationship seems to reverse at menopause. These disparities are probably due to hormonal factors, especially the female sex hormone estrogen seems to have a protective influence on the development of atherosclerotic plaques premenopausal. The underlying mechanisms of the effect of estrogens on the vessel wall are still insufficiently investigated. In this study, menopause related effects on leukocyte distribution and function as well on platelets and their aggregational response will be evaluated.

Key facts

Study ID

NCT05985447

Run by

Heinrich-Heine University, Duesseldorf

People needed

180

Starts

2022-03-07

Expected to finish

2026-12-01

Last updated by the study team

2023-08-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 18 years
• Male, female, diverse patients with current treatment in the Department of Cardiology, Pneumology and Angiology.
• Persons who are able to understand and follow the instructions of the study staff
• Written informed consent

You may not qualify if…

• Age < 18 years
• Lack of written consent to participate in the study
• coagulation disorders

Where it is running

• University-Hospital Düsseldorf Division of Cardiology, Pulmonary Disease and Vascular Medicine — Düsseldorf, Germany (enrolling)

Full record on ClinicalTrials.gov

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