Neurobiological Similarities of Tinnitus and PTSD
Completed
Conditions studied: Posttraumatic Stress Disorder, Tinnitus
In brief
Psychiatric distress caused by PTSD may increase attention toward tinnitus, as well as perceived loudness and discomfort. It is important to understand how tinnitus-related distress and PTSD negatively interact together, in order to develop more effective therapeutic approaches. Understanding symptoms and neurobiological mechanisms using functional magnetic resonance imaging (fMRI), can lead to the necessary knowledge to develop effective interventions for individuals who suffer from both conditions.
Key facts
- Study ID
- NCT05981391
- Run by
- The University of Texas Health Science Center at San Antonio
- People needed
- 64
- Starts
- 2021-02-04
- Expected to finish
- 2024-11-01
- Last updated by the study team
- 2025-07-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male and female DEERS eligible veterans and active duty service members, ages 18 and above
- preferred language is English and able to read and speak English at a 6th grade level
- those with PTSD (T\&P; PO) must meet full criteria for PTSD diagnosis based on the DSM-5 and assessed by an independent evaluator using the CAPS-5
- those with chronic, constant tinnitus (T\&P, TO) will be identified by self-report and confirmed with the audiometric assessment.
You may not qualify if…
- psychiatric hospitalization in the last 12 months
- significant cognitive impairment determined by inability to comprehend screening assessment
- psychiatric problems and/or high suicide risk warranting immediate intervention
- neurobiological disorders, Meniere's disease
- Temporomandibular disorders that affect tinnitus, per self-report
- history of major head trauma with loss of consciousness for 20 minutes or more as determined by the History of Head Injuries questionnaire
- history of seizures
- conditions that would prevent completion of fMRI scan (any type of electronic, mechanical, or magnetic implant, coil, filter, or stent, any type of surgical clip or staple, shunt, any type of metal object, hearing aid, spinal fusion, halo vest, IV access port, eyelid spring, artificial eye, artificial heart valve, biostimulator, severe hyperacusis)
- active conductive pathology/hearing loss as determined by audiometric assessment.
- Those with tinnitus (T\&P; TO) will be excluded if their tinnitus is intermittent, objective, or pulsatile, or present for less than 6 months.
Where it is running
- UT Health San Antonio — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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