Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study

Completed · Not applicable

Conditions studied: HIV Infections

In brief

Through the proposed Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement (SCOPE) study, the investigators will design and evaluate an overdose prevention and HIV prevention study among people who use drugs (PWUD). Specifically, SCOPE will provide access to drug-checking services for PWUD to better understand the contents of the drug supply, in combination with PrEP for those who are HIV-, to both reduce overdose and HIV among PWUD in Baltimore City.

Key facts

Study ID

NCT05977881

Run by

Johns Hopkins Bloomberg School of Public Health

People needed

493

Starts

2023-07-28

Expected to finish

2026-05-01

Last updated by the study team

2026-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older,
• self-reports having used illicit stimulants or opioids at least once in the past 3 months,
• self-reports being HIV negative
• reports injection drug use in the past 6 months OR reports at least one of the following indicators of sexual HIV risk exposure in the past 6 months:
• Sexually Transmitted Infection (STI) diagnosis in the past 6 months
• "Condom-less" vaginal or anal sex in the past 6 months
• Willing to provide a urine sample for urine drug screening of substances
• Willing to undergo rapid HIV testing
• Willing to undergo STI testing

You may not qualify if…

• Determined to be too high or drunk or cognitively impaired, less than 18 years of age
• unwilling to provide all required biological specimens (Phase 3 only)
• unwilling/unable to give consent

Where it is running

• Johns Hopkins School of Public Health — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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