Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients

Completed · Not applicable

Conditions studied: Pneumonia, Pneumonia, Viral, Pneumonia, Bacterial

In brief

The goal of this prospective randomized study is to improve antibiotic use among hospitalized patients with suspected pneumonia. An alert was built into the electronic health record to guide use of diagnostic testing based on probability of bacterial pneumonia. Patients with test results suggesting viral infection will be randomized to either: (1) receive a structured communication from the antimicrobial stewardship team to de-escalate antibiotics or (2) usual care.

Key facts

Study ID

NCT05976581

Run by

Jonathan Baghdadi

People needed

107

Starts

2023-11-01

Expected to finish

2025-05-31

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients admitted to the University of Maryland Medical Center or University of Maryland Medical Center-Midtown Campus who are prescribed antibiotics for suspected community-acquired respiratory infection.
• Protocol-based diagnostic testing supports possible viral infection, either by positive molecular test or low procalcitonin value.

You may not qualify if…

• Hospitalization for >72 hours prior to protocol-based diagnostic testing.
• Previous molecular testing for viral infection during the same hospital encounter.
• Severely immunosuppressed, defined as having hematologic malignancy, solid organ tumor on chemotherapy, or solid organ transplant on immunosuppression

Where it is running

• University of Maryland Medical Center - Midtown Campus — Baltimore, Maryland, United States
• University of Maryland Medical Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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