Identifying and Treating Depression in the Orthopaedic Trauma Population

Recruiting now · Phase 4

Conditions studied: Depression

In brief

The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?

Key facts

Study ID

NCT05976347

Run by

Wake Forest University Health Sciences

People needed

100

Starts

2025-06-25

Expected to finish

2027-05-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients presenting to an Orthopaedic trauma clinic for the first time following operative extremity fracture or any pelvis fracture
• A score of greater than or equal to 5 on the Patient Health Questionnaire-9 (PHQ-9) at first post- operative visit
• Age 18 or older
• Speak English or Spanish

You may not qualify if…

• Currently taking medication to treat depression
• Contraindication/allergy to one of the study medications
• Bipolar disorder of psychotic disorder
• Endorse suicidal ideation

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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