Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
Recruiting now · Not applicable
Conditions studied: Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy, Sepsis, Severe, Septic Shock, Septic Syndrome
In brief
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when vancomycin should and should not be used * Unit-level feedback on overall vancomycin use within and across centers * Clinician education.
Key facts
- Study ID
- NCT05975671
- Run by
- Children's Hospital of Philadelphia
- People needed
- 52500
- Starts
- 2023-08-21
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2025-09-19
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Children's Healthcare of Atlanta — Atlanta, Georgia, United States (enrolling)
- Johns Hopkins Children's Center — Baltimore, Maryland, United States (enrolling)
- St. Louis Children's Hospital — St Louis, Missouri, United States (enrolling)
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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