COAgulation Disorders in Ischaemic and Haemorrhagic Stroke
Recruiting now
Conditions studied: Ischemic Stroke, Haemorrhagic Stroke, Aneurysmal Subarachnoid Hemorrhage
In brief
In this study the investigators will assess both procoagulant and anticoagulant pathways using thrombin generation and platelet function tests; as well as neuronal ischemia using cell free DNA in all patients presenting with ischaemic and haemorrhagic stroke (including aneurysmal subarachnoid haemorraghe). Also the cross-talk between inflammation and thrombosis, so-called thrombo-inflammation is further investigated. As such the investigators aim to characterise the patient's coagulation profile before administration of any treatment. By assessing these pathways the investigators strive to detect specific markers to predict vital and functional outcome at 3 months in these patients. Finally the investigators may provide new pathophysiological insights in the course of disease following these events that can possibly improve future therapeutic strategies.
Key facts
- Study ID
- NCT05974111
- Run by
- Ziekenhuis Oost-Limburg
- People needed
- 350
- Starts
- 2023-05-02
- Expected to finish
- 2025-08-31
- Last updated by the study team
- 2024-11-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Presenting at the hospital with ischaemic stroke, haemorrhagic stroke, aneurysmal subarachnoid haemorrhage or any other type of non-traumatic, intracranial bleeding
- In patients with minor ischemic stroke (NIHSS <= 4) only baseline lab sampling will be performed (T0 and T0B).
You may not qualify if…
- Refusal of participation by patient or legal representative
- Traumatic intracranial (subdural, subarachnoid, epidural haematoma) bleeding
- Patients receiving treatment with interference on coagulation (pro / anti) before first sampling: in this group of patients the coagulation assessment at presentation will be excluded, further lab sampling is performed according to protocol.
- Patients categorized as having stroke mimic will be excluded from analysis afterwards
Where it is running
- Ziekenhuis Oost-Limburg — Genk, Belgium (enrolling)
Full record on ClinicalTrials.gov
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