Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes

Recruiting now · Not applicable

Conditions studied: Hypoglycemia, Type1diabetes

In brief

Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D). In a previous study, it was observed in people without diabetes that fasting can be detrimental to the hormonal and hepatic responses to insulin-induced hypoglycemia. In the experiments described herein, the impact fasting has on hypoglycemic counterregulation in people with T1D will be determined.

Key facts

Study ID

NCT05973799

Run by

University of Cincinnati

People needed

10

Starts

2019-10-10

Expected to finish

2024-12-31

Last updated by the study team

2024-09-03

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• males and females of any race or ethnicity
• non-obese (BMI < or = to 30)
• have a diagnosis of type 1 diabetes
• C-peptide negative

You may not qualify if…

• pregnant women
• cigarette smoking
• Taking inflammation-targeting steroids (e.g., prednisone).
• Taking medications targeting adrenergic signaling (e.g., beta-blockers, bronchodilators).
• Hematocrit less than 33%.
• Presence of HIV or hepatitis (due to their deleterious effects on the liver).
• The presence of cardiovascular or peripheral vascular disease.
• The presence of neuropathy, retinopathy or nephropathy.
• A detection of the presence of any other disease or condition by one of the study doctors, that would be expected to confound the responses to insulin-induced hypoglycemia or make participation in the study dangerous to the individual.

Where it is running

• University of Cincinnati — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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