Prospective Validation of an EHR-based Pancreatic Cancer Risk Model

Running, not enrolling

Conditions studied: Pancreatic Adenocarcinoma, Predictive Cancer Model

In brief

The goal of this prospective observational cohort study is to validate a previously developed pancreatic cancer risk prediction algorith (the PRISM model) using electronic health records from the general population. The main questions it aims to answer are: * Will a pancreatic cancer risk model, developed on routine EHR data, reliably and accurately predict pancreatic cancer in real-time? * What is the average time from model deployment and risk prediction, to the date of pancreatic cancer development and what is the stage of pancreatic cancer at diagnosis? The risk model will be deployed on data from individuals eligible for the study. Each individual will be assigned a risk score and tracked over time to assess the model's discriminatory performance and calibration.

Key facts

Study ID

NCT05973331

Run by

Beth Israel Deaconess Medical Center

People needed

6134060

Starts

2023-04-21

Expected to finish

2026-09-01

Last updated by the study team

2026-04-22

Who can join

Age: 40 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male and females age >= 40 years from 44 US HCOs from the TriNetX platform
• at least 2 clinical encounters to the HCO, within the last year, before the study start date

You may not qualify if…

• Personal history of PDAC or current PDAC
• Age below 40
• Notes on sampling method: no sampling was performed. All eligible individuals are included in this study.

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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