Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines

Completed · Not applicable

Conditions studied: Parkinson Disease

In brief

Twenty-five participants with PD utilizing the Medtronic Percept PC DBS system will be enrolled for this project and complete a single bout of both FE and VE. The 150-minute experimental session will be completed in the OFF antiparkinsonian and Off-DBS state.

Key facts

Study ID

NCT05972759

Run by

The Cleveland Clinic

People needed

25

Starts

2023-08-15

Expected to finish

2026-02-12

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult with a diagnosis of PD by a movement disorders neurologist
• Previous placement, at least six months, of bilateral Medtronic Precept DBS as standard of care treatment for their PD.
• Stable and clinically optimized DBS parameters for three months prior to enrollment.
• Demonstrate the ability to safely mount and dismount a recumbent exercise cycle with an upright back.
• Willingness to withhold antiparkinsonian medication and DBS stimulation.
• Exercise clearance using the American College of Sports Medicine (ACSM) Pre-participation Health Screen: a. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provider prior to participation; b. Those who choose not to obtain physician clearance will not be eligible for participation.

You may not qualify if…

• Diagnosis of dementia or any neurocognitive impairment that compromises the ability to provide informed consent.
• A musculoskeletal issue that limits one's ability to cycle
• Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) that impacts motor or cognitive function
• Uncontrolled cardiovascular risk factor such as a current cardiac arrhythmia, uncontrolled hypertension, untreated deep vein thrombosis, etc.

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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