A Study of mRNA-1018 Pandemic Influenza Candidate Vaccines in Healthy Adults
Completed · Phase 1/Phase 2
Conditions studied: Influenza
In brief
The purpose of this Phase 1/2 study is to generate sufficient safety and immunogenicity data of mRNA-1018 pandemic influenza candidate vaccines in healthy adults ≥18 years of age to enable the initiation of a large Phase 3 trial with one selected vaccine candidate. The study will be conducted in 2 Parts (Part A and Part B) that will enroll and run concurrently. Part A of the study will evaluate 4 vaccine candidates (H5N8, H7N9, H5 only, and H7 only). Part B of the study will evaluate a single vaccine candidate (H5 only-CG).
Key facts
- Study ID
- NCT05972174
- Run by
- ModernaTX, Inc.
- People needed
- 1504
- Starts
- 2023-07-10
- Expected to finish
- 2024-07-16
- Last updated by the study team
- 2025-07-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- CenExel RCA — Hollywood, Florida, United States
- Velocity Clinical Research — Savannah, Georgia, United States
- Johnson County Clin-Trials — Lenexa, Kansas, United States
- DM Clinical Research — Southfield, Michigan, United States
- Velocity Clinical Research — Lincoln, Nebraska, United States
- Velocity Clinical Research Providence — East Greenwich, Rhode Island, United States
- DM Clinical Research — Sugar Land, Texas, United States
- DM Clinical Research — Tomball, Texas, United States
- J. Lewis Research, Inc/Jordan River Family Medicine — South Jordan, Utah, United States
- Royal Victoria Infirmary — Newcastle upon Tyne, England, United Kingdom
- Southampton General Hospital — Southampton, England, United Kingdom
- University Hospitals Birmingham — Birmingham, London, United Kingdom
- Bradford Teaching Hospitals NHS Foundation Trust — Bradford, London, United Kingdom
- University Hospitals — Bristol, London, United Kingdom
- Cardiff and Vale University — Cardiff, London, United Kingdom
- Northern Care Alliance — Salford, London, United Kingdom
- Royal Cornwall Hospital — Truro, London, United Kingdom
- North Wales Clinical Research Centre — Wrexham, London, United Kingdom
- Quadram Institute NNUH CRF — Norwich, Norfolk, United Kingdom
- Lakeside Healthcare Research Unit — Corby, Northamptonshire, United Kingdom
- Western Hospital Edinburgh — Edinburgh, United Kingdom
- Royal Free Hospital — London, United Kingdom
- Guy's and St Thomas' NHS Foundation Trust - St Thomas' Hospital — London, United Kingdom
- Chelsea and Westminster Hospital — London, United Kingdom
- St Georges Vaccine Institute Cranmer Terrace — London, United Kingdom
Full record on ClinicalTrials.gov
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